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From First Principles — Destroying Tumors With Sound: Histotripsy with Dr. Zhen Xu
Scout ratingSCOUT· 36%1h 04m·2026-11-05·Science

Destroying Tumors With Sound: Histotripsy with Dr. Zhen Xu

From First Principles · 66

Can sound destroy a tumor without an incision? Dr. Zhen Xu joins Krishna Choudhary to explain histotripsy: focused ultrasound that creates tiny bubbles to mechanically break apart tissue, without relying on heat. From a noise complaint in a University of Michigan lab to the Edison system, Xu traces the unexpected…

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What people are saying

“When I first read about this thing called histotripsy having been FDA approved for liver tumors, I thought, why couldn't this be used to help shrink my enlarged prostate (benign prostate hyperplasia)? BPH is treated with a bunch of differen…”

— @MR-lk9tc · YouTube comment

“Love that engineering quote. Get a bigger hammer 😂😂”

— @underwms · YouTube comment

“Yet more ways the trump administration has regressed society by killing federal funding for countless programs. Think how many histotripsies won’t make it past the early research phase.”

— @RockLurker · YouTube comment

“Excellent interview, fascinating guest, smashed it as usual.”

— @RockLurker · YouTube comment

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