

Nobel Prize in Medicine 2026 Explained: Optogenetics (EP 61)
How do you prove what a brain cell actually does? The 2026 Nobel Prize in Medicine celebrates a remarkable answer: give cells a light-sensitive protein, then switch their activity on or off with light. In Episode 61 of From First Principles, Lester Nare and Krishna Choudhary explain optogenetics from the ground up and…

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What people are saying
“It’s so cruel that so many deserving scientists are left out. I hope these people feel proud that their work pushing humanity forward is their greatest prize, that their work is resoundingly meaningful, as many people don’t get to do such i…”
“First thing came to my mind was your prediction, great job guys. I am a great fan of your podcast”
“it is crazy that this video has only 19 comments even if it is 10 hours old”
“I've never really paid that much attention to the Nobel stuff, but you guys really made it interesting and now I'm hooked!”
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