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Latent Space: The AI Engineer Podcast

Latent.Space

The main Latent Space podcast: AI engineering, Forward Deployed Engineering, AI for science, and ⚡ Lightning episodes. Other feeds: Engineering and FDE: https://podcast.latent.space/eng.xml; Science: https://podcast.latent.space/science.xml; Misc (Lightning and other shows):…

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Latent Space: The AI Engineer Podcast

[One Million AI Engineer Special] How Stanford Teaches AI-Native Engineering &#x2014; Mihail Eric, Monaco

Deep Dive: Anthropic S-1 Myths and Mythos &#x2014; Jamin Ball, Altimeter

Controlling Biology - Fabian Theis, Helmholtz Munich

&#x26a1; Behind Latent Space: A Rare Look Inside the Pod | AIEi Shanghai

&#x26a1;&#xfe0f; The 2026 Software Factory Standard &#x2014; Zach Lloyd, Warp.dev

Building Legal Agents When You Can't See the Data - Jacob Lauritzen, CTO of Legora

Using Agents for Long-Horizon Financial Work &#x2014; Aman Singh, Arca

&#x26a1; Building ChatGPT for Finance &#x2014; Joseph Kim, OpenAI's Head of Financial Services

Why Agents Love Supabase

How Anthropic ships the #1 LLM in the World safely: Separating the Brain from the Hands

Why Agents Love Supabase

&#x26a1; An Eval for AI Scientists That Knows the Answer Key - Ian Quigley, Leash Bio

Why AI Compute Comes in Rectangles — Erik Bernhardsson, Modal CEO

Why AI Compute Comes in Rectangles &#x2014; Erik Bernhardsson, Modal CEO

You are the Team — Anekha Sokhal, Moshi

The Recommendation Engine for Commodity Traders &#x2014; Anekha Sokhal, Moshi

AI for the Fortune 2000: How Tenex Builds an AI-Native SDLC &#x2014; Alex Lieberman & CJ Hess

AI for the Fortune 2000: How Tenex Builds an AI-Native SDLC — Alex Lieberman & CJ Hess

The Programmable Data Center — Evan Conrad, SF Compute

The Programmable Data Center &#x2014; Evan Conrad, SF Compute

Lab-in-the-Loop at Compute Speed — Ian Quigley, Leash Bio

&#x1f52c; Lab-in-the-Loop at Compute Speed &#x2014; Ian Quigley, Leash Bio

Dyna-2: General Purpose Physical Agents with Hour-Long Autonomy &#x2014; Jason Ma, Dyna Robotics

Dyna-2: General Purpose Physical Agents with Hour-Long Autonomy — Jason Ma, Dyna Robotics

Why AlphaFold Didn't Solve Protein Folding — Pushmeet Kohli, Google DeepMind & Sal Candido, Biohub

&#x1f52c; Why AlphaFold Didn't Solve Protein Folding &#x2014; Pushmeet Kohli, Google DeepMind & Sal Candido, Biohub

Synthesis Superintelligence: from Semiconductors to Superconductors — Periodic Labs’ Liam Fedus and Ekin Dogus Cubuk

&#x1f52c; Synthesis Superintelligence: from Semiconductors to Superconductors &#x2014; Periodic Labs&#x2019; Liam Fedus and Ekin Dogus Cubuk

&#x26a1;&#xfe0f; Which GPU Clouds Are Actually Good? | ClusterMAX 3.0

Academia is for Ambition &#x2014; Alex Zhang, MIT

Academia is for Ambition — Alex Zhang, MIT

Why Dwarkesh is Wrong about Computer Use + How OpenAI shipped its Jev competitor in 1 Week

Claude Code&#x2019;s Next Era &#x2014; Thariq Shihipar, Anthropic

Claude Code’s Next Era — Thariq Shihipar, Anthropic

OpenRouter: from Seed to Stripe — with OpenRouter’s Alex Atallah & AMP’s Anjney Midha

OpenRouter: from Seed to Stripe &#x2014; with OpenRouter&#x2019;s Alex Atallah & AMP&#x2019;s Anjney Midha

Runway&#x2019;s WorldPrompt and the Engineering of Real-Time Worlds

Runway’s WorldPrompt and the Engineering of Real-Time Worlds

&#x1f52c; Bio-security is an AI Arms Race - Eric Nguyen (CEO, Radical Numerics)

🔬Bio-security is an AI Arms Race - Eric Nguyen (CEO, Radical Numerics)

&#x1f52c; An Oscar, Two Asteroids, and the Algorithm in Your sklearn: John Platt on AI for Science

🔬 An Oscar, Two Asteroids, and the Algorithm in Your sklearn: John Platt on AI for Science

Jev: System One models for Prod, not God &#x2014; with Diogo Almeida, CEO, TypeSafe AI

Jev: System One models for Prod, not God — with Diogo Almeida, CEO, TypeSafe AI

&#x26a1;&#xfe0f; A Worm With 302 Neurons Inspired Their Architecture &#x2014; Ramin Hasani, Liquid AI

Underwriting Superintelligence: Backing Agents you can Sue &#x2014; Rune Kvist, AIUC

Underwriting Superintelligence: Backing Agents you can Sue — Rune Kvist, AIUC

Humanity’s Last Invention — Richard Socher of Recursive

Humanity&#x2019;s Last Invention &#x2014; Richard Socher of Recursive

🔬“We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing

&#x1f52c; &#x201c;We have foundation models for language, not for physics&#x201d; &#x2014; Anima Anandkumar, Bren Professor of Computing

&#x23ed;&#xfe0f; Forward Deployed: Voice AI on what works in 2026

Simulation: the new Scaling Law &#x2014; Joon Sung Park, Simile AI

Simulation: the new Scaling Law — Joon Sung Park, Simile AI

&#x26a1;&#xfe0f; Exo: Harnesses should see their own code and logs &#x2014; Alex Krentsel, UC Berekeley / Google Research

&#x1f52c; The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery

🔬The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery

The Inference Engineering Masterclass &#x2014; Philip Kiely & Ali Taha, Baseten

The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten

Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI

Codex from 0 to 10M Users: Building ChatGPT Work &#x2014; Akshay Nathan, OpenAI

Inside the Model Factory — Eiso Kant, Poolside AI

Inside the Model Factory &#x2014; Eiso Kant, Poolside AI

&#x1f52c; Causal Models Need Causal Data - Xaira&#x2019;s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist)

🔬Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist)

&#x1f52c; The Lab of the Future Should Feel Like a Data Center &#x2014; Andy Beam & Rafa G&#xf3;mez-Bombarelli, Lila Sciences

🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences

&#x26a1;&#xfe0f; Podcast Crossover: AIE, AGI, frontier lab strategy with &#x200b; &#x2068;@matthew_berman&#x2069; and @swyxtv

Why AI Infrastructure must evolve for Agent Experience &#x2014; Akshat Bubna, Modal CTO

Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO

&#x1f52c; The Coolest Diffusion Research Isn't in LLMs &#x2014; Evan Feinberg & Sergey Edunov, Genesis Molecular AI

🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI

&#x26a1;&#xfe0f; The Blueprint for Autonomous Work Agents | Gavriel Cohen, NanoClaw

Why the Frontier Ecosystem must be Open &#x2014; Matei Zaharia and Reynold Xin, Databricks

Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks

Red-Teaming after Mythos &#x2014; Zico Kolter & Matt Fredrikson, Gray Swan

Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan

&#x26a1;&#xfe0f; Every product of the future will be a living system &#x2014; Ronak Malde, Trajectory.ai

The Professor of Outputmaxxing — Anjney Midha, AMP

[One Million AI Engineer Special] How Stanford Teaches AI-Native Engineering — Mihail Eric, Monaco

Deep Dive: Anthropic S-1 Myths and Mythos — Jamin Ball, Altimeter

⚡ Behind Latent Space: A Rare Look Inside the Pod | AIEi Shanghai

⚡️ The 2026 Software Factory Standard — Zach Lloyd, Warp.dev

Using Agents for Long-Horizon Financial Work — Aman Singh, Arca

⚡ Building ChatGPT for Finance — Joseph Kim, OpenAI's Head of Financial Services

⚡ An Eval for AI Scientists That Knows the Answer Key - Ian Quigley, Leash Bio

Why AI Compute Comes in Rectangles — Erik Bernhardsson, Modal CEO

The Recommendation Engine for Commodity Traders — Anekha Sokhal, Moshi

AI for the Fortune 2000: How Tenex Builds an AI-Native SDLC — Alex Lieberman & CJ Hess

The Programmable Data Center — Evan Conrad, SF Compute

🔬 Lab-in-the-Loop at Compute Speed — Ian Quigley, Leash Bio

Dyna-2: General Purpose Physical Agents with Hour-Long Autonomy — Jason Ma, Dyna Robotics

🔬 Why AlphaFold Didn't Solve Protein Folding — Pushmeet Kohli, Google DeepMind & Sal Candido, Biohub

🔬 Synthesis Superintelligence: from Semiconductors to Superconductors — Periodic Labs’ Liam Fedus and Ekin Dogus Cubuk

⚡️ Which GPU Clouds Are Actually Good? | ClusterMAX 3.0

Academia is for Ambition — Alex Zhang, MIT

Claude Code’s Next Era — Thariq Shihipar, Anthropic

OpenRouter: from Seed to Stripe — with OpenRouter’s Alex Atallah & AMP’s Anjney Midha

Runway’s WorldPrompt and the Engineering of Real-Time Worlds

🔬 Bio-security is an AI Arms Race - Eric Nguyen (CEO, Radical Numerics)

🔬 An Oscar, Two Asteroids, and the Algorithm in Your sklearn: John Platt on AI for Science

Jev: System One models for Prod, not God — with Diogo Almeida, CEO, TypeSafe AI

⚡️ A Worm With 302 Neurons Inspired Their Architecture — Ramin Hasani, Liquid AI

Underwriting Superintelligence: Backing Agents you can Sue — Rune Kvist, AIUC

Humanity’s Last Invention — Richard Socher of Recursive

🔬 “We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing

⏭️ Forward Deployed: Voice AI on what works in 2026

Simulation: the new Scaling Law — Joon Sung Park, Simile AI

⚡️ Exo: Harnesses should see their own code and logs — Alex Krentsel, UC Berekeley / Google Research

🔬 The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery

The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten

Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI

Inside the Model Factory — Eiso Kant, Poolside AI

🔬 Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist)

🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences

⚡️ Podcast Crossover: AIE, AGI, frontier lab strategy with ⁨@matthew_berman⁩ and @swyxtv

Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO

🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI

⚡️ The Blueprint for Autonomous Work Agents | Gavriel Cohen, NanoClaw

Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks

Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan

⚡️ Every product of the future will be a living system — Ronak Malde, Trajectory.ai

The Professor of Outputmaxxing — Anjney Midha, AMP

🔬 The Self-Driving Lab — Joseph Krause, Radical AI

⚡️ Making DeepSeek v4 outperform Opus 4.7 with Taste — @AhmadAwais , CommandCode.ai

Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs

🔬 Scaling Past Informal AI - Carina Hong, Axiom Math

⚡️ Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build

GitHub's plan for Agents — Kyle Daigle, GitHub

Why Video Agent models are next — Ethan He, xAI Grok Imagine

The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray

🔬 ESM: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub

⚡️ Google's Open AI Strategy — Omar Sanseviero, Google DeepMind

⚡️ Why you should build Science Fiction — Sunil Pai, Cloudflare

Giving Agents Computers — Ivan Burazin, Daytona

Railway: The Agent-Native Cloud — Jake Cooper

🔬 The Autonomous Drone Tech Stack & Economics of Drones — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion

AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge

⚡️ Senior Dev: This "Grill Me" Prompt Is Going Viral Among Top Engineers

🔬 Doing Vibe Physics — Alex Lupsasca, OpenAI

⚡️ Competing with ChatGPT and Sierra, building a $10M ARR company — Yasser Elsaid, Founder, Chatbase

Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition

Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO

🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik

⚡️ How to turn Documents into Knowledge: Graphs in Modern AI — Emil Eifrem, CEO Neo4J

Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion

⚡️ The best engineers don't write the most code. They delete the most code. — Stay Sassy

Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony

Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun

Mistral: Voxtral TTS, Forge, Leanstral, & what's next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample

🔬 Why There Is No "AlphaFold for Materials" — AI for Materials Discovery with Heather Kulik

Dreamer: the Personal Agent OS — David Singleton

Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop

⚡️ Monty: the ultrafast Python interpreter by Agents for Agents — Samuel Colvin, Pydantic

Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer

NVIDIA's AI Engineers: Agent Inference at Planetary Scale and "Speed of Light" — Nader Khalil (Brev), Kyle Kranen (Dynamo)

⚡️ OpenClaw's Memory Sucks and the fix is simple — Dhravya Shah, Supermemory

Every Agent Needs a Box — Aaron Levie, Box

⚡️ Polsia: Solo Founder Tiny Team from 0 to 1m ARR in 1 month & the future of Self-Running Companies