The show, episode by episode

Latent Space: The AI Engineer Podcast

Latent.Space

The podcast by and for AI Engineers! In 2025, over 10 million readers and listeners came to Latent Space to hear about news, papers and interviews in Software 3.0. We cover Foundation Models changing every domain in Code Generation, Multimodality, AI Agents, GPU Infra and more, directly from the founders, builders,…

227 episodes tracked Similar shows

Latent Space: The AI Engineer Podcast

Runway’s WorldPrompt and the Engineering of Real-Time Worlds

🔬Bio-security is an AI Arms Race - Eric Nguyen (CEO, Radical Numerics)

🔬 An Oscar, Two Asteroids, and the Algorithm in Your sklearn: John Platt on AI for Science

Jev: System One models for Prod, not God — with Diogo Almeida, CEO, TypeSafe AI

Underwriting Superintelligence: Backing Agents you can Sue — Rune Kvist, AIUC

Humanity’s Last Invention — Richard Socher of Recursive

🔬“We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing

Simulation: the new Scaling Law — Joon Sung Park, Simile AI

🔬The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery

The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten

Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI

Inside the Model Factory — Eiso Kant, Poolside AI

🔬Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist)

🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences

Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO

🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI

Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks

Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan

The Professor of Outputmaxxing — Anjney Midha, AMP

🔬 The Self-Driving Lab — Joseph Krause, Radical AI

Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs

🔬Scaling Past Informal AI - Carina Hong, Axiom Math

⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build

GitHub's plan for Agents — Kyle Daigle, GitHub

Why Video Agent models are next — Ethan He, xAI Grok Imagine

The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray

🔬ESM: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub

Giving Agents Computers — Ivan Burazin, Daytona

Railway: The Agent-Native Cloud — Jake Cooper

The Autonomous Drone Tech Stack & Economics of Drones — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion

AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge

🔬Doing Vibe Physics — Alex Lupsasca, OpenAI

Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition

AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026)

Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO

🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik

Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion

Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony

Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"

Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun

Mistral: Voxtral TTS, Forge, Leanstral, & what's next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample

🔬Why There Is No "AlphaFold for Materials" — AI for Materials Discovery with Heather Kulik

Dreamer: the Personal Agent OS — David Singleton

Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop

Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer

NVIDIA's AI Engineers: Agent Inference at Planetary Scale and "Speed of Light" — Nader Khalil (Brev), Kyle Kranen (Dynamo)

Cursor's Third Era: Cloud Agents

Every Agent Needs a Box — Aaron Levie, Box

METR’s Joel Becker on exponential Time Horizon Evals, Threat Models, and the Limits of AI Productivity

[LIVE] Anthropic Distillation & How Models Cheat (SWE-Bench Dead) | Nathan Lambert & Sebastian Raschka

🔬Searching the Space of All Possible Materials — Prof. Max Welling, CuspAI

Claude Code for Finance + The Global Memory Shortage: Doug O'Laughlin, SemiAnalysis

⚡️The End of SWE-Bench Verified — Mia Glaese & Olivia Watkins, OpenAI Frontier Evals & Human Data

Bitter Lessons in Venture vs Growth: Anthropic vs OpenAI, Noam Shazeer, World Labs, Thinking Machines, Cursor, ASIC Economics — Martin Casado & Sarah Wang of a16z

Owning the AI Pareto Frontier — Jeff Dean

🔬Beyond AlphaFold: How Boltz is Open-Sourcing the Future of Drug Discovery

The First Mechanistic Interpretability Frontier Lab — Myra Deng & Mark Bissell of Goodfire AI

🔬 Automating Science: World Models, Scientific Taste, Agent Loops — Andrew White

Captaining IMO Gold, Deep Think, On-Policy RL, Feeling the AGI in Singapore — Yi Tay

Brex’s AI Hail Mary — With CTO James Reggio

Artificial Analysis: Independent LLM Evals as a Service — with George Cameron and Micah-Hill Smith

[State of Evals] LMArena's $1.7B Vision — Anastasios Angelopoulos, LMArena

[NeurIPS Best Paper] 1000 Layer Networks for Self-Supervised RL — Kevin Wang et al, Princeton

[State of Code Evals] After SWE-bench, Code Clash & SOTA Coding Benchmarks recap — John Yang

[State of Post-Training] From GPT-4.1 to 5.1: RLVR, Agent & Token Efficiency — Josh McGrath, OpenAI

[State of RL/Reasoning] IMO/IOI Gold, OpenAI o3/GPT-5, and Cursor Composer — Ashvin Nair, Cursor

[State of AI Startups] Memory/Learning, RL Envs & DBT-Fivetran — Sarah Catanzaro, Amplify

One Year of MCP — with David Soria Parra and AAIF leads from OpenAI, Goose, Linux Foundation

Steve Yegge's Vibe Coding Manifesto: Why Claude Code Isn't It & What Comes After the IDE

⚡️GPT5-Codex-Max: Training Agents with Personality, Tools & Trust — Brian Fioca + Bill Chen, OpenAI

SAM 3: The Eyes for AI — Nikhila & Pengchuan (Meta Superintelligence), ft. Joseph Nelson (Roboflow)

⚡️Jailbreaking AGI: Pliny the Liberator & John V on Red Teaming, BT6, and the Future of AI Security

AI to AE's: Grit, Glean, and Kleiner Perkins' next Enterprise AI hit — Joubin Mirzadegan, Roadrunner

The Future of Email: Superhuman CTO on Your Inbox As the Real AI Agent (Not ChatGPT) — Loïc Houssier

World Models & General Intuition: Khosla's largest bet since LLMs & OpenAI

After LLMs: Spatial Intelligence and World Models — Fei-Fei Li & Justin Johnson, World Labs

⚡️ 10x AI Engineers with $1m Salaries — Alex Lieberman & Arman Hezarkhani, Tenex

Anthropic, Glean & OpenRouter: How AI Moats Are Built with Deedy Das of Menlo Ventures

⚡ Inside GitHub’s AI Revolution: Jared Palmer Reveals Agent HQ & The Future of Coding Agents